Mild traumatic brain injuries (mTBI) such as concussions are arguably one of the most pressing concerns in sports today, with an estimated 2-4 million cases every year in youth sports alone. The potential short- and long-term impacts on the health…

Dysautonomia is an umbrella term referring to a group of several medical conditions that cause a malfunction of the Autonomic Nervous System (ANS). Cancer can affect the ANS in a variety of ways and while cancer therapies have increased patient survival…

In the U.S. alone, over 20% of adults experienced a mental illness in 2019; a problem that has only worsened with the current pandemic. Mental health conditions, which include post-traumatic stress disorder, depression, suicidal ideation, and substance use disorder, are…

Neurodegenerative conditions, such as Parkinson’s Disease (PD), affect regions in the brain that play a key role in cognitive and motor function, leading to impairments of movement, speech production, memory, reasoning, planning, reflexes, among others. Assessment of disease state is…

Ananda Mondal (PI) The primary objective of this research is to investigate and analyze the complex phenomena of disease progression at the protein network level using three graph theoretic concepts – clique, bipartite graph, and diffusion kernel. Computational studies of…

Fahad Saeed (PI) Database peptide search algorithms deduce peptides from mass spectrometry data. There has been substantial effort in improving their computational efficiency to achieve larger and more complex systems biology studies. However, modern serial and high-performance computing (HPC) algorithms…

Fahad Saeed (PI) Historically, there have been two contrasting approaches for inferring peptides from mass-spectrometry data, i.e., de novo sequencing and database searching. The de novo approach tries to transform spectral space into peptide space by predicting individual amino acids…

Fahad Saeed (PI) It is widely known that defining and diagnosing mental disorders is a difficult process due to overlapping nature of symptoms, and lack of a biological test that can serve as a definite and quantified gold standard. Mental…